Effect of Trospium Chloride on Cognitive Function in Women Aged 50 and Older: A Randomized Trial.

Objectives: This study aimed to investigate the effect of trospium chloride on cognitive function in postmenopausal women treated for overactive bladder (OAB).

Methods: Randomized double-blind placebo-controlled trial conducted from April 2013 to April 2015. Women aged 50 years or older seeking treatment for OAB were randomized to either trospium chloride XR 60 mg daily or placebo.

Effect of anticholinergic use for the treatment of overactive bladder on cognitive function in postmenopausal women.

Background: Overactive bladder (OAB) is a common condition affecting the elderly. The mainstay of treatment for OAB is medical therapy with anticholinergics. However, adverse events have been reported with this class of drugs, including cognitive changes.