Publications by authors named "Christine M Juhr"
Article Synopsis
- * The study examined valvular interstitial cells (VICs) from diseased versus healthy valves, finding that those from diseased valves showed changes indicating a shift toward a more fibrous cell type, increased signs of aging, and reduced ability to grow and survive.
- * Specific microRNAs (miRNAs) linked to cell behavior were significantly downregulated in VICs from diseased valves, indicating a possible link between decreased miRNAs and the progression of MMVD, supporting the idea that
J Extracell Vesicles
July 2017
Article Synopsis
- Myxomatous mitral valve disease (MMVD) is similar to mitral valve prolapse (MVP) in humans, but there's currently no medical treatment to slow its progression, highlighting the necessity for better understanding of its molecular pathology.
- The study analyzed exosomal miRNA from different groups of dogs (healthy, with MMVD, and with MMVD-related heart failure) to investigate potential biomarkers associated with the disease and aging.
- Significant increases in specific exosomal miRNAs (like miR-181c and miR-495) were recorded in dogs with MMVD-related heart failure, indicating that exosomal miRNA changes might be more relevant to the disease compared to total plasma miRNA.
