A virologic pilot study of valacyclovir in infectious mononucleosis.

Background: Infectious mononucleosis decreases the productivity of many college students and Epstein-Barr virus (EBV) infection may result in long-term immune damage.

Objectives: Evaluate the antiviral effect of valacyclovir during EBV-related acute infectious mononucleosis and explore potential clinical benefits.

Study Design: University students who presented during the first 7 days of illness were randomized to receive valacyclovir 3g/day for 14 days or not.