Publications by authors named "Christine Lohse"

Objective: To compare the utility of intraoperative electrically evoked auditory brainstem response (eABR) and electrically evoked stapedial reflex testing (eSRT) for cochlear nerve integrity monitoring during simultaneous translabyrinthine resection of vestibular schwannoma (VS) and cochlear implantation.

Study Design: Historical cohort study.

Setting: Tertiary academic referral center.

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Objective: To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation.

Study Design: Retrospective multi-institutional cohort study.

Setting: Eleven tertiary academic medical centers across Germany, Denmark, and the United States.

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Objective: To analyze cases of medial migration of vestibular schwannomas to propose an underlying mechanism.

Study Design: Retrospective chart review.

Patients: Ten patients from one institution with sporadic vestibular schwannomas that demonstrated medial migration toward the cerebellopontine angle on serial imaging were reviewed.

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Article Synopsis
  • The study aims to evaluate how different cochlear dose parameters affect hearing outcomes in patients with sporadic vestibular schwannoma (VS) who have serviceable hearing after undergoing stereotactic radiosurgery (SRS).
  • A total of 205 patients were analyzed over a period from 2007 to 2022, revealing that 62% of patients maintained serviceable hearing at 2 years, while this dropped to 15% by 10 years post-treatment.
  • Results showed a significant association between increased minimum cochlear dose and faster decline in hearing, indicating that this dose parameter should be a key consideration in planning radiosurgery for VS patients.
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Article Synopsis
  • - This study compares cochlear implant (CI) outcomes for speech perception in patients with sporadic vestibular schwannoma (VS) treated through observation, radiosurgery, or microsurgery.
  • - Of the 100 patients analyzed, those who underwent microsurgery had poorer speech perception scores compared to those who were observed or treated with radiosurgery, with only 61% achieving open-set speech perception after microsurgery.
  • - The findings suggest that cochlear implants can be beneficial for sporadic VS patients, particularly those managed by observation or radiosurgery, as these groups showed significantly better outcomes in achieving open-set speech perception.
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Objective: To report the feasibility and potential utility of monitoring acoustic hearing on awake patients using intraoperative behavioral responses to threshold and suprathreshold stimuli while undergoing cochlear implantation (CI) under local anesthesia, without any form of sedation.

Study Design: Retrospective review of the first five cases performed by one surgeon.

Setting: Tertiary care academic medical center.

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Objective: Stereotactic radiosurgery (SRS) is increasingly used for small-to-medium-sized sporadic vestibular schwannoma (VS) and is associated with good tumor control and low-risk of adverse radiation-associated events. The exact mechanism of VS tumor control is unknown but may relate to microvascular hyalinization and resultant tumoral ischemia. This study examined associations of microvascular risk factors with outcomes following SRS.

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Article Synopsis
  • Over the past two decades, there has been a growing focus on diagnosing and managing inner ear schwannomas, especially regarding hearing rehabilitation through cochlear implants, but the terminology used to classify these tumors has been inconsistent and complex.
  • At the Ninth Quadrennial Conference in May 2023 in Bergen, Norway, experts reached a consensus to standardize terminology, ultimately agreeing on the term "inner ear schwannoma (IES)" to clearly describe tumors affecting the eighth nerve in the cochlea, vestibule, or semicircular canals.
  • The newly established classifications break down these tumors into three complexity levels: low (intravestibular, intracochlear), intermediate (with internal
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Objective: To evaluate the long-term changes in sporadic vestibular schwannoma (VS) disease-specific quality-of-life (QOL) outcomes.

Study Design: Prospective longitudinal study using the Penn Acoustic Neuroma Quality of Life (PANQOL) Scale.

Setting: National survey.

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Background And Purpose: Vestibular schwannomas (VSs) are benign neurogenic tumors commonly associated with progressive unilateral hearing loss, tinnitus, and vestibular symptoms. Growing evidence links signal changes in the VS-adjacent labyrinth with sensorineural hearing loss. This study seeks to quantify the association of labyrinthine signal on post-gadolinium 3D-FLAIR imaging correlates with hearing loss and to evaluate potential longitudinal changes over time.

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Objective: To develop and compare various models for risk stratification in chromophobe renal cell carcinoma (chrRCC). Models have been developed to predict progression-free (PFS) and cancer-specific survival (CSS) following surgery for localized renal cell carcinoma (RCC). Notably, chromophobe RCC (chrRCC) is not included in American Urological Association (AUA) risk stratification, as nuclear grading is not recommended.

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Purpose: Ipsilateral local recurrence (LR) after partial nephrectomy (PN) for renal cell carcinoma (RCC) may result from a metachronous tumor or PN bed recurrence. To date, literature has predominantly reported ipsilateral LRs collectively, although the pathophysiology and prognostic implications of these event may be distinct. We sought to assess variables associated with LR and evaluated associations of LR with metastasis and death from RCC.

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Purpose: AUA guidelines prioritize nephron sparing in patients with preexisting chronic kidney disease (CKD). However, few studies analyze long-term renal function in patients with preoperative severe CKD who undergo extirpative renal surgery. Herein, we compare the hazard of progression to end-stage kidney disease (ESKD) following partial nephrectomy (PN) and radical nephrectomy (RN) among patients with preoperative severe CKD.

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Introduction: Surgical techniques for sellar reconstruction include no reconstruction, use of synthetic materials, autologous grafts, and/or vascularized flaps. The aim of this study was to conduct a multi-center study comparing the efficacy and postoperative morbidity associated with different sellar reconstruction techniques.

Methods: A retrospective chart review of patients who underwent endoscopic transsphenoidal surgery for pituitary tumors from five participating sites between January 2021 and March 2023 was performed.

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Purpose: The AUA guidelines introduced a new risk group stratification system based primarily on tumor stage and grade to guide surveillance for patients treated surgically for localized renal cell carcinoma (RCC). We sought to evaluate the predictive ability of these risk groups using progression-free survival (PFS) and cancer-specific survival (CSS), and to compare their performance to that of our published institutional risk models.

Materials And Methods: We queried our Nephrectomy Registry to identify adults treated with radical or partial nephrectomy for unilateral, M0, clear cell RCC, or papillary RCC from 1980 to 2012.

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Objective: To describe outcomes of patients with sporadic vestibular schwannoma (VS) who underwent repeat stereotactic radiosurgery (SRS) after primary SRS failure.

Study Design: Multi-institutional historical cohort study.

Setting: Five tertiary care referral centers.

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Objective: To examine current practices and opinions of cochlear implant (CI) providers with respect to post-implantation auditory training.

Methods: A survey was submitted to the American Cochlear Implant Alliance membership that reviewed current practice and opinions with respect to post-implantation auditory training for adult CI recipients.

Main Outcome Measures: Review of respondent practice, center volume, role on CI team, and current usage and opinions surrounding auditory training, including resources used and schedule of use.

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Importance: Management of sporadic vestibular schwannoma with radiosurgery is becoming increasingly common globally; however, limited data currently characterize patient outcomes in the setting of microsurgical salvage for radiosurgical failure.

Objective: To describe the clinical outcomes of salvage microsurgery following failed primary stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) among patients with sporadic vestibular schwannoma.

Design, Setting, And Participants: This was a cohort study of adults (≥18 years old) with sporadic vestibular schwannoma who underwent salvage microsurgery following failed primary SRS/FSRT in 7 vestibular schwannoma treatment centers across the US and Norway.

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Introduction: There has been historical controversy regarding the extent of resection in the management of pleomorphic adenomas. This study aims to evaluate the extent of surgery and short-term postoperative outcomes of partial superficial parotidectomy (PSP) for the management of pleomorphic adenomas at a tertiary, high-volume center.

Methods: A retrospective chart review of patients who underwent PSP was performed.

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