Publications by authors named "Christine Lobo"
Background: In infants and children with fractures from an unclear cause, osteogenesis imperfecta (OI) is often included as a potential etiology. In infants and children with OI there exists a gap in the published literature regarding the fracture pattern seen at the time of diagnosis. As an additional aid to the diagnosis of OI, we sought to characterize the fracture patterns in infants and children at the time of their diagnosis.
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- Triple-negative breast cancers (TNBC) are a subgroup of breast cancers that lack key hormone receptors and occur more frequently in African American women, making up about 15% of all breast cancer cases.
- The poor outcomes for TNBC patients are partly due to the absence of effective therapeutic targets; although the epidermal growth factor receptor (EGFR) is overexpressed in many TNBC cases, current EGFR inhibitors have limited success in treating metastatic cases.
- Research has shown that combining mTOR inhibitors, like rapamycin, with EGFR inhibitors, such as lapatinib, enhances treatment effectiveness by increasing cancer cell death and reducing tumor growth, suggesting this combination therapy could potentially improve outcomes for certain TNBC patients.