Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model.

Introduction: Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood.

Methods: One hundred eight animals were divided into 18 groups (6 animals).

Effects of environmental exposure to iron powder on healthy and elastase-exposed mice.

Prolonged exposure to iron powder and other mineral dusts can threaten the health of individuals, especially those with COPD. The goal of this study was to determine how environmental exposure to metal dust from two different mining centers in Brazil affects lung mechanics, inflammation, remodeling and oxidative stress responses in healthy and elastase-exposed mice. This study divided 72 male C57Bl/6 mice into two groups, the summer group and the winter group.

Trace metals and PAHs in topsoils of the University campus in the megacity of São Paulo, Brazil.

The aim of this study is to discuss the concentration distribution, composition and possible sources of trace metals and 13 PAHs in topsoils of the University campus, in the city of São Paulo, the largest city of South America. Mineralogy and granulometry of topsoils (0-10 cm) samples, were determined and As, Ba, Cd, Co, Cr, Cu, Mo, Ni, Pb, Sb, V, Zn, Hg, Pt, Pd and PAHs concentrations were quantified in the bulk fraction. The average clay content of soils was 221±61.

Inventory and assessment of geosites to stimulate regional sustainable management: the northern coast of the state of São Paulo, Brazil.

The reviewed and integrated geoheritage inventory of the northern coast of the state of São Paulo, Brazil, resulted in 43 geosites distributed in eight geological frameworks. The selected geosites are representative of a geological history from the Neoproterozoic (Brasiliano-Pan African Cycle) to the recent, covering a minimum 700-Ma timespan. Considering the dynamic character of geoheritage inventories, the results presented in this work were based on previous local, town-based surveys, which were reviewed under the light of new geological data and geoconservation methods.