Prevalence of structural central nervous system abnormalities in early-onset type 1 diabetes mellitus.

Objective: To characterize the effects of severe hypoglycemia on the developing brain in children with early-onset type 1 diabetes mellitus (T1DM).

Study Design: Children diagnosed with T1DM before age 6 years were studied. Those with prospectively monitored severe hypoglycemia (coma/seizure; n = 32) were compared with age-matched peers (n = 30) with no history of such events using magnetic resonance imaging.

Increase in type 2 diabetes in children and adolescents in Western Australia.

Objectives: To document diagnosis rates of type 2 diabetes mellitus in children and adolescents in Western Australia over the past 12 years, the clinical characteristics of these patients and any comorbidities.

Design: Review of a prospectively recorded diabetes database.

Setting: Tertiary paediatric referral centre (the only such centre in WA).