Publications by authors named "Christine Katharina Maurer"
Bioorg Med Chem
September 2023
Article Synopsis
- Hematopoietic progenitor kinase 1 (HPK1) is an important target in immune oncology research because it regulates key signaling pathways in immune cells.
- Genetic deletion of HPK1 in T cells enhances their response to activation, and HPK1 knockout mice show improved anti-tumor effects.
- The study details the development of effective HPK1 inhibitors through structure-based drug design, achieving strong potency and increased IL-2 cytokine secretion, which could enhance anti-tumor immune responses.
