Publications by authors named "Christine J Neilson"

Objectives: To systematically identify, appraise, and summarise published evidence on individual socioeconomic and health-related factors associated with human papillomavirus (HPV) vaccination initiation and completion among females of paediatric age.

Study Design: A global systematic review with meta-analysis (PROSPERO: CRD42023445721).

Methods: We performed a literature search in December 2022 and supplemented the search on August 1, 2023.

View Article and Find Full Text PDF
Article Synopsis
  • Adaptive designs (ADs) in clinical trials make the testing process more flexible and can save time and money.
  • Many people in the medical field don’t fully understand how these designs work, so a review has been done to explain their use in research.
  • The study looked at a lot of research reports from 2010 to 2020 and found that most ADs were used in trials for adults, especially for cancer treatments, with a smaller number for children.
View Article and Find Full Text PDF
Article Synopsis
  • HPV vaccination rates among women, especially adult females, are significantly lower than the targets set by the World Health Organization.
  • A systematic review analyzed individual factors affecting both the initiation and completion of HPV vaccination among adult females, identifying socioeconomic and health characteristics that play a role.
  • Results showed that White women, those with higher education and health insurance, and younger individuals had significantly higher odds of both initiating and completing the vaccination series, with additional factors influencing completion.
View Article and Find Full Text PDF

Introduction: Using data in research often requires that the data first be de-identified, particularly in the case of health data, which often include Personal Identifiable Information (PII) and/or Personal Health Identifying Information (PHII). There are established procedures for de-identifying structured data, but de-identifying clinical notes, electronic health records, and other records that include free text data is more complex. Several different ways to achieve this are documented in the literature.

View Article and Find Full Text PDF

The literature search underpins data collection for all systematic reviews (SRs). The SR reporting guideline PRISMA, and its extensions, aim to facilitate research transparency and reproducibility, and ultimately improve the quality of research, by instructing authors to provide specific research materials and data upon publication of the manuscript. Search strategies are one item of data that are explicitly included in PRISMA and the critical appraisal tool AMSTAR2.

View Article and Find Full Text PDF

Not much is known about correlations between country-level characteristics and country-level numbers of COVID-19 cases and mortalities. Using data from the World Health Organization and other international organisations, we summarised country-level COVID-19 case and mortality counts per 100,000 population, and COVID-19 case fatality rate from January 2020 to August 2021. We conducted adjusted linear regression analysis to assess relationships between these counts/rate and certain country-level characteristics.

View Article and Find Full Text PDF

Objectives: The number needed to vaccinate (NNV) quantifies the effectiveness of vaccination programs. We summarised the published data on NNV against herpes zoster to inform vaccination policies.

Methods: We systematically identified studies based on a priori established and registered methods.

View Article and Find Full Text PDF

Background: Knowledge synthesis (KS) reviews rely on good quality literature searches to capture a complete set of relevant studies, and peer review of the search strategy is one quality control mechanism that contributes to better quality reviews. Guidelines for peer review of electronic search strategies (PRESS) have been available since 2008.

Objectives: This overview provides a snapshot of KS indexed in Scopus, published between 2009 and 2018, that reported peer review of the literature search strategy.

View Article and Find Full Text PDF

Introduction: Vaccination is considered to be the most practical and effective preventative measure against influenza. It is highly recommended for population subgroups most at risk of developing complications, including pregnant women. However, seasonal influenza vaccine uptake remains suboptimal among pregnant women, even in jurisdictions with universal vaccination.

View Article and Find Full Text PDF

Cancer patients are among high-risk individuals for whom seasonal influenza vaccine (SIV) is recommended, but rates of vaccination in this subpopulation remain suboptimal; even in jurisdictions with universal influenza vaccination programs. We sought to summarize the evidence to better understand the determinants of SIV uptake (vaccine receipt) among cancer patients. We searched MEDLINE, Embase, and CINAHL from 2000 to February 12, 2020, focusing on articles on the determinants of seasonal influenza vaccination among cancer patients, published in English.

View Article and Find Full Text PDF

Engaging in health-promoting behaviours has health benefits for people with prediabetes or diabetes. People experience negative affect after diagnoses, which can impede self-regulation of health behaviours. Self-compassion, extending care to oneself in difficult times, can mitigate negative affect and promote self-regulation.

View Article and Find Full Text PDF

Despite the availability of a universal influenza vaccination program in the United States and Canada, seasonal influenza vaccine (SIV) uptake among the elderly remains suboptimal. Understanding the factors that determine SIV uptake in this important population subgroup is essential for designing effective interventions to improve seasonal influenza vaccination among the elderly. We evaluated the determinants of SIV uptake in the elderly in the United States and Canada.

View Article and Find Full Text PDF

Importance: Nonpublication of research results in considerable research waste and compromises medical evidence and the safety of interventions in child health.

Objective: To replicate, compare, and contrast the findings of a study conducted 15 years ago to determine the impact of ethical, editorial, and legislative mandates to register and publish findings.

Design, Setting, And Participants: In this cohort study, abstracts accepted to the Pediatric Academic Societies (PAS) meetings from May 2008 to May 2011 were screened in duplicate to identify phase 3 randomized clinical trials enrolling pediatric populations.

View Article and Find Full Text PDF

Background: Research partnership approaches, in which researchers and stakeholders work together collaboratively on a research project, are an important component of research, knowledge translation, and implementation. Despite their growing use, a comprehensive understanding of the principles, strategies, outcomes, and impacts of different types of research partnerships is lacking. Generating high-quality evidence in this area is challenging due to the breadth and diversity of relevant literature.

View Article and Find Full Text PDF

Background: Although children have historically been excluded from clinical trials (CTs), many require medicines tested and approved in CTs, forcing health care providers to treat their pediatric patients based on extrapolated data. Unfortunately, traditional randomized CTs can be slow and resource-intensive, and they often require multi-center collaboration. However, an adaptive design (AD) framework for CTs could be used to increase the efficiency of pediatric CTs by incorporating prospectively planned modifications to CT methods without undermining the integrity or validity of the study.

View Article and Find Full Text PDF

Introduction: The aim of this paper is to provide a protocol for a systematic review assessing the effectiveness of evidence from randomised controlled trials comparing fetal alcohol spectrum disorders pharmacological and non-pharmacological interventions with placebo/dummy interventions or usual standards of care in children and adolescents (<18 years old).

Methods And Analysis: The following electronic databases will be searched: Medline (Ovid), Cumulative Index of Nursing and Allied Health Plus with Full text (EBSCO), Cochrane Central Register of Controlled Trials (Cochrane Library-Wiley), PsycINFO (ProQuest) and Proquest DissertationsandTheses will be searched from inception to March 2017 for relevant citations of published trials using individualised search strategies prepared for database. We will also search the reference lists of relevant articles and conference proceedings.

View Article and Find Full Text PDF

Background: While glucose tablets have been advocated for treating symptomatic hypoglycaemia in awake patients, dietary sugars may be more convenient. We performed a systematic review to compare the impact of these treatment options on the relief of symptomatic hypoglycaemia, time to resolution of symptoms, blood glucose levels, complications and hospital length of stay.

Method: We searched PubMed, Embase and the Cochrane Library through 28 June 2016 and assessed the quality of evidence using the Grades of Recommendation, Assessment, Development and Evaluation approach.

View Article and Find Full Text PDF

This pilot study evaluated a research method for examining the efficacy of screen capture tutorials in teaching database search skills. This is not a results-oriented paper but rather describes the facets and testing of a mixed methods protocol. The lessons learned can be applied to a result-oriented study with a larger sample size and to the development of methods for similar studies.

View Article and Find Full Text PDF

The Saskatchewan Health Information Resources Partnership (SHIRP) provides library instruction to Saskatchewan's health care practitioners and students on placement in health care facilities as part of its mission to provide province-wide access to evidence-based health library resources. A portable computer lab was assembled in 2007 to provide hands-on training in rural health facilities that do not have computer labs of their own. Aside from some minor inconveniences, the introduction and operation of the portable lab has gone smoothly.

View Article and Find Full Text PDF