Publications by authors named "Christine J Duch"
Article Synopsis
- * Researchers successfully identified two specific proteins from the sheeppox virus that could be used in a new indirect enzyme-linked immunosorbent assay (ELISA), showing high sensitivity and specificity for detecting antibodies in infected animals.
- * This new ELISA test is promising for efficient screening of capripoxvirus infections in livestock, offering a standardized method without the use of live pathogens, though it may not detect antibodies in vaccinated animals.
Epitopes involved in a protective immune response to Hendra virus (HeV) (Henipavirus, Paramxyoviridae) were investigated by generating five neutralizing monoclonal antibodies (mAbs) to the virus attachment protein (G) of HeV (HeV G) and sequencing of the G gene of groups of neutralization-escape variants selected with each mAb. Amino acid substitutions occurred at eight distinct sites on HeV G. Relationships between these sites were investigated in binding and neutralization assays using heterologous combinations of variants and mAbs.
View Article and Find Full Text PDF