Publications by authors named "Christine Hong Ngoc Che Thai"
Purpose: Residual cancer burden (RCB) index after neoadjuvant chemotherapy (NAC) is highly prognostic in patients with breast cancer (BC) but does not account for subtype or the precise impact of residual nodal burden (RNB). We aimed to precisely de ne the effect of RNB on survival by subtypes.
Methods: Adult women with non-metastatic BC diagnosed from 2006-2021 in the National Cancer Database (NCDB) who received NAC followed by surgery within 8 months were included.
Differential prognostic value of residual nodal burden in breast cancer subtypes.
Breast Cancer Res Treat
September 2024
Article Synopsis
- - The study investigates how residual nodal burden (RNB) after neoadjuvant chemotherapy (NAC) affects survival rates in breast cancer patients, particularly focusing on different cancer subtypes.
- - Analyzing data from over 51,000 patients, researchers found that increased RNB significantly raises the risk of mortality, with triple-negative breast cancer (TNBC) showing the most substantial decrease in 5-year survival rates compared to other subtypes.
- - The findings highlight the importance of considering breast cancer subtypes when assessing prognosis and developing future treatment strategies for patients with residual disease after chemotherapy.
Introduction: Axillary response to neoadjuvant endocrine therapy (NET) for the treatment of hormone receptor-positive breast cancer (HR+ BC) is not well-described. This study was designed to characterize nodal response after NET.
Methods: Patients receiving NET followed by curative intent surgery at a comprehensive cancer center from 1998 to 2022 in a prospectively collected registry were included.