Publications by authors named "Christine Germeys"
Article Synopsis
- Researchers found that inflammation and energy problems can harm nerve cells in ALS.
- They discovered that lowering a protein called EGLN2 helped protect these nerve cells in zebrafish and mice.
- The study showed that EGLN2 is important for controlling inflammation in brain cells of ALS patients.
Growing evidence suggests that aberrant energy metabolism could play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, studies applying advanced technologies to investigate energy metabolism in ALS remain scarce. The rapidly growing field of metabolomics offers exciting new possibilities for ALS research.
View Article and Find Full Text PDFEnergy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (iPSCs) versus iPSC-derived MNs and subsequently compared MNs from ALS patients carrying FUS mutations to their CRISPR/Cas9-corrected counterparts.
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