Publications by authors named "Christine Georgelin"
We present in this paper a global methodology for the spike detection in a biological context of fluorescence recording of GnRH-neurons calcium activity. For this purpose we first propose a simple stochastic model that could mimic experimental time series by considering an autoregressive AR(1) process with a linear trend and specific innovations involving spiking times. Estimators of parameters with asymptotic normality are established and used to set up a statistical test on estimated innovations in order to detect spikes.
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- Episodic release of GnRH is crucial for reproductive function, driven by a synchronization of GnRH neuron activity, but the exact mechanisms behind this synchronization are not fully understood.
- The study investigates the role of glial cell communication via gap junctions in regulating GnRH neuron activity, identifying that glial cells expressing connexin-43 are present near GnRH fibers.
- Experimental results show that blocking these gap junctions reduces GnRH secretion and disrupts neuronal synchronization, but these effects can be reversed, indicating the importance of glial cells in maintaining GnRH neuron function.
We describe a mathematical model of digestion in the small intestine. The main interest of our work is to consider simultaneously the different aspects of digestion i.e.
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