Bhalin, an Essential Cytoskeleton-Associated Protein of Linking BILBO1 of the Flagellar Pocket Collar with the Hook Complex.

Background: In most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP. Investigations of essential cytoskeleton-associated structures located at this site have revealed a number of essential proteins. The protein BILBO1 is located at the neck of the FP in a structure called the flagellar pocket collar (FPC) and is essential for biogenesis of the FPC and parasite survival.

Intrabody-Induced Cell Death by Targeting the T. brucei Cytoskeletal Protein BILBO1.

Trypanosoma brucei belongs to a genus of protists that cause life-threatening and economically important diseases of human and animal populations in Sub-Saharan Africa. T. brucei cells are covered in surface glycoproteins, some of which are used to escape the host immune system.