Metformin turns 62 in pharmacotherapy: Emergence of non-glycaemic effects and potential novel therapeutic applications.

Metformin is the most commonly prescribed oral antidiabetic medication. Direct/indirect activation of Adenosine Monophosphate-activated protein kinase (AMPK) and non-AMPK pathways, amongst others, are deemed to explain the molecular mechanisms of action of metformin. Metformin is an established insulin receptor sensitising antihyperglycemic agent, is highly affordable, and has superior safety and efficacy profiles.

Cardioprotective Effects of Metformin.

Metformin, routinely used as first-line drug in the treatment of type 2 diabetes, has been shown to have cardioprotective effects beyond its glycemic control. These have been attributed to increases in Akt concentrations and activation of protein kinases in the RISK pathways, which prevent the mPTP from opening and rupturing it and therefore, protects myocyte viability. In myocardial infarction and subsequent reperfusion, metformin activation of AMPK promotes glycolysis and keeps the mPTP closed.

Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model.

Background: Hypoglycemic effects of grapefruit juice are well known but the effects of naringin, its main flavonoid on glucose intolerance and metabolic complications in type 1 diabetes are not known.

Objectives: To investigate the effects of naringin on glucose intolerance, oxidative stress and ketonemia in type 1 diabetic rats.

Methods: Sprague-Dawley rats divided into 5 groups (n = 7) were orally treated daily with 3.

The 'Holy Mother' and the shadow: revisiting Jung's work on the quaternity.

Through a series of clinical vignettes, this paper considers the impact of religious belief, specifically Roman Catholicism, on the psyche and development of mind; in particular, there will be a focus on the influences of the conflation of maternal beliefs with a Catholic belief system when the loss or absence of the father is a primary factor. Further, it will be shown in case examples that split off aspects of the personal shadow such as conflicted and aggressive emotions related to mother and father can conflate with the collective numinous and religious aspects of the 'dark side' of the God-representation and result in 'religious' persecutory symptoms. This has a debilitating effect on the emerging personality, leaving it prone to fears, anxieties and psychotic pockets of experience when there is a numinous persecutory shadow in the background that affects and limits the individual's development.

Juveniles' knowledge of the court process: results from instruction from an electronic source.

Our study first determined what juveniles know about the juvenile court process. Second, it evaluated a DVD designed to be a systematic and simple way to improve this knowledge. A pre- and posttest design was used with two pilot samples and two samples from the population of interest.

An under-active or over-active internal world? An exploration of parallel dynamics within psyche and soma, and the difficulty of internal regulation, in patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

This paper explores the dynamics brought into analytic work when there is a symmetric fusion between psyche and soma within the patient. It will consider how such a fusion may emerge from reverberations between physical constitution and a lack of maternal attunement, containment and reflective function. I will describe the work with a patient, Jane, who was diagnosed with Myalgic Encephalomyelitis (ME) during the course of her analysis.