Recurrence-Free Survival Analysis in Locally Advanced Pheochromocytoma: First Appraisal.

Context: The behavior of locally advanced pheochromocytoma (LAP) remains unknown.

Objective: We characterized the population with LAP and recurrence-free survival (RFS).

Methods: This retrospective multicentric study was run within the ENDOCAN-COMETE network and French Group of Endocrine Tumors (GTE) from 2003 to 2018, including patients from 11 French referral centers with LAP as defined by capsular invasion, vascular invasion, adipose tissue invasion, and/or positive locoregional lymph nodes at diagnosis without evidence of distant metastasis.

[Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers].

Thyroglobulin (Tg) is a high molecular weight glycoprotein located mainly in thyroid follicles, where thyroid hormones are synthesized and stored. In patients with differentiated thyroid cancer of follicular origin, serum Tg levels become undetectable following total thyroidectomy and iodine-131 remnant ablation. It is a key biomarker to follow-up patients with differentiated thyroid cancer, in combination with neck ultrasound monitoring.

[Biomarkers in endocrinology].

TSH assay is the best parameter of the thyroid function. For adults, the normal interval of TSH concentrations range from 0.4 to 4 mUI/L.