Publications by authors named "Christine De Graff"
Article Synopsis
- - The 2014-2016 Ebola outbreak underscored the risk of nosocomial spread of the virus, particularly among healthcare workers, emphasizing the need for better preparedness in handling Ebola cases.
- - A study involved setting up an ICU within a BSL4 lab, where researchers infected non-human primates with Ebola and collected various biological samples to evaluate the risk factors in routine care.
- - Results showed that while the virus was detectable in blood early on, other bodily fluids were only positive later; maintaining good hygiene practices helped mitigate risks associated with droplet spread and surface contamination.
Article Synopsis
- The published article originally left out the names of four authors.
- The authors who were omitted are Logan Banadyga, Alixandra Albietz, Brad Pickering, and Gary Wong.
- This notice highlights the error in the author attribution in the article.
Background: There are currently limited data for the use of specific antiviral therapies for the treatment of Ebola virus disease (EVD). While there is anecdotal evidence that supportive care may be effective, there is a paucity of direct experimental data to demonstrate a role for supportive care in EVD. We studied the impact of ICU-level supportive care interventions including fluid resuscitation, vasoactive medications, blood transfusion, hydrocortisone, and ventilator support on the pathophysiology of EVD in rhesus macaques infected with a universally lethal dose of Ebola virus strain Makona C07.
View Article and Find Full Text PDFZika virus (ZIKV) is an emerging pathogen causally associated with serious sequelae in fetuses, inducing fetal microcephaly and other neurodevelopment defects. ZIKV is primarily transmitted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been documented. Moreover, exposure of type-I interferon knockout mice to ZIKV results in severe damage to the testes, epididymis and sperm.
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