Nuclear expression of CXCR4 in tumor cells of non-small cell lung cancer is correlated with lymph node metastasis.

The stromal-derived factor 1alpha (CXCL12)/chemokine receptor CXCR4 system plays an important role in the metastatic process of a variety of cancers, with CXCR4 frequently expressed by tumor cells homing to CXCL12-rich compartments. The current study evaluated a possible association of CXCR4 expression with lymph node metastasis in primary non-small cell lung cancer. CXCR4 expression levels were evaluated using immunohistology in 46 non-small cell lung cancer specimens of patients without or with lymph node involvement (N0 = 24, N1/N2/N3 = 22).

[Mental distress and the use of psychiatric and psychotherapeutic treatments services: results of the Study of Health in Pomerania].

Objective: Due to the lack of adequate data on the need of psychiatric and psychotherapeutic care in the community, an evidence-based goal directed development of treatment systems in socioeconomically poorer regions in former Eastern Germany is not feasible.

Method: A community sample from the Study of Health in Pomerania (N = 4310) was investigated with the "Beschwerdenliste" from von Zerssen. The met and the unmet need of care were estimated.