Publications by authors named "Christine A Caneba"
Aging is associated with conduit artery stiffening that is a risk factor for and can precede hypertension and ventricular dysfunction. Increases in mitochondria DNA (mtDNA) frequency have been correlated with aging. Mice with a mutation in the encoding domain (D257A) of a proof-reading deficient version of mtDNA polymerase-γ (POLG) have musculoskeletal features of premature aging and a shortened lifespan.
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- Anoikis resistance allows cancer cells to survive without attachment to their usual environment, a trait common in epithelial cancers, particularly ovarian cancer.
- The "Warburg effect" highlights cancer cells' preference for glycolysis, which impacts their energy production regardless of oxygen availability.
- Recent studies suggest that the metabolic behavior of ovarian cancer cells varies greatly based on their invasive capabilities and whether they are attached or detached from their environment, with highly invasive cells showing increased energy production and migration abilities in detached conditions.