Publications by authors named "Christine A Bowen"
Microglia are resident immune cells of the brain and regulate its inflammatory state. In neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease-associated microglia (DAM). DAM express higher levels of proinflammatory signaling molecules, like STAT1 and TLR2, and show transitions in mitochondrial activity toward a more glycolytic response.
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- Microglia are essential immune cells in the central nervous system that adapt and change in response to their environment, especially during disease.
- In conditions like neurodegenerative diseases, they shift from their normal state to various forms, influencing disease progression.
- The review emphasizes the importance of proteomic profiling of microglia to uncover new therapeutic targets, particularly focusing on insights gained from studies related to Alzheimer’s disease.
Kv1.3 potassium channels, expressed by proinflammatory central nervous system mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating neuroinflammation in Alzheimer's disease (AD). The molecular characteristics of Kv1.
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