Publications by authors named "Christina-Lin Brown"
Background: Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT.
View Article and Find Full Text PDFBackground: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival.
Methods: A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed.
Article Synopsis
- Recent studies on epicardial derived cells (EPDCs) using mouse models show they play a significant role in the formation of structures at the atrioventricular (AV) junction, including the AV sulcus, annulus fibrosus, and AV valve leaflets.
- The specific mechanisms of how EPDCs contribute to these tissues and the role of bone morphogenetic protein (Bmp) signaling, particularly through its receptor Alk3, have not been well understood.
- Research revealed that deleting the Alk3 receptor in epicardial cells leads to underdeveloped AV structures and reduced EPDC presence in valve leaflets, highlighting Alk3-mediated Bmp signaling as crucial for both the early development and maturation of AV tissues