Publications by authors named "Christina Yuh-Ron Hung"
Background: MUC16 is a heavily glycosylated cell surface mucin cleaved in the tumor microenvironment to shed CA125. CA125 is a serum biomarker expressed by > 95% of non-mucinous advanced stage epithelial ovarian cancers. MUC16/CA125 contributes to the evasion of anti-tumor immunity, peritoneal spread and promotes carcinogenesis; consequently, it has been targeted with antibody-based passive and active immunotherapy.
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- The study investigates the impact of immune checkpoint inhibitor (ICI) myocarditis on global circumferential strain (GCS) and global radial strain (GRS), which are measures of heart function, comparing 75 ICI myocarditis patients to 50 controls without myocarditis.
- Pre-treatment GCS and GRS were similar in both groups, but those with myocarditis had significantly lower GCS and GRS during treatment.
- Lower GCS and GRS correlated with a higher risk of cardiovascular events, indicating their potential as better indicators of heart health compared to traditional markers like cardiac troponin T and left ventricular ejection fraction.