Publications by authors named "Christina Vestal"
The Seven S Criteria for Evaluating the Performance of a MALDI Mass Spectrometer for MSI.
J Am Soc Mass Spectrom
December 2020
Our goal in this work is to evaluate a new combination linear/reflector MALDI-TOF instrument toward satisfying all "7S criteria" for the ideal MSI mass spectrometer. The linear analyzer satisfies all of the 7 criteria except for Specificity. The new instrument described here adds a reflector to provide up to 50,000 mass resolving power with ppm mass accuracy and with no sacrifice in speed, spatial resolution, and sensitivity demonstrated earlier for the linear MALDI-TOF.
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- - A new high-performance linear MALDI-TOF mass spectrometer offers enhanced spatial resolution and speed using a novel ion optics system.
- - The instrument features a grounded ion source and effectively transfers and detects ions across a wide mass range, resulting in improved sensitivity and precision.
- - The system's capabilities are showcased through imaging experiments on pancreatic tissue samples from rats and mice.