Inhibitory deficits in Klinefelter syndrome are secondary to deficits in the auditory and motor domain.

Deficits in several cognitive domains are prevalent in men with Klinefelter Syndrome (KS). Verbal deficits are among the most characteristic cognitive impairments of KS, yet other cognitive domains also exhibit deficits. Executive functions, especially working memory capacity and inhibitory control, are frequently affected as well.

On the (un)reliability of common behavioral and electrophysiological measures from the stop signal task: Measures of inhibition lack stability over time.

Response inhibition, the intentional stopping of planned or initiated actions, is often considered a key facet of control, impulsivity, and self-regulation. The stop signal task is argued to be the purest inhibition task we have, and it is thus central to much work investigating the role of inhibition in areas like development and psychopathology. Most of this work quantifies stopping behavior by calculating the stop signal reaction time as a measure of individual stopping latency.

Partial response electromyography as a marker of action stopping.

Response inhibition is among the core constructs of cognitive control. It is notoriously difficult to quantify from overt behavior, since the outcome of successful inhibition is the lack of a behavioral response. Currently, the most common measure of action stopping, and by proxy response inhibition, is the model-based stop signal reaction time (SSRT) derived from the stop signal task.

The P300 as marker of inhibitory control - Fact or fiction?

Inhibitory control, i.e., the ability to stop or suppress actions, thoughts, or memories, represents a prevalent and popular concept in basic and clinical neuroscience as well as psychology.

Neuropsychological functions, sleep, and mental health in adults with Klinefelter syndrome.

A few studies have examined neuropsychological functions, sleep, and mental health combined in Klinefelter syndrome (KS; 47,XXY). We investigated neuropsychological functions with standard tests, sleep with actigraphy, and self-reported mental health in 30 men with KS (Mean age = 36.7 years) compared to 21 controls (Mean age = 36.

tDCS over the inferior frontal gyri and visual cortices did not improve response inhibition.

The ability to cancel an already initiated response is central to flexible behavior. While several different behavioral and neural markers have been suggested to quantify the latency of the stopping process, it remains unclear if they quantify the stopping process itself, or other supporting mechanisms such as visual and/or attentional processing. The present study sought to investigate the contributions of inhibitory and sensory processes to stopping latency markers by combining transcranial direct current stimulation (tDCS), electroencephalography (EEG) and electromyography (EMG) recordings in a within-participant design.