Early Handling Exerts Anxiolytic Effects and Alters Brain Mitochondrial Dynamics in Adult High Anxiety Mice.

Early handling (EH), the brief separation of pups from their mother during early life, has been shown to exert beneficial effects. However, the impact of EH in a high anxiety background as well as the role of brain mitochondria in shaping EH-driven responses remain elusive.Here, we used a high (HAB) vs.

Idiopathic thrombocytopenic purpura in childhood: twenty years of experience in a single center.

Background: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder with a variable clinical course.

Methods: A retrospective analysis was carried out of ITP patients presenting to a pediatric hematology-oncology department during a period of 20 years, with a focus on treatment and outcome.

Results: One hundred and twenty-four cases were recorded (mean patient age, 8.

Acquired somatic mutations in the microsatellite DNA, in children with bronchial asthma.

Objectives: High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults.

Working Hypothesis: The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma.

Methodology: DNA was extracted from sputum and blood cells of 27 children (10.