High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study.

Objective: Adrenal crisis (AC) is a life-threatening complication of adrenal insufficiency (AI), which according to retrospective data represents a significant clinical complication. Here we aimed to prospectively assess incidence of AC and mortality associated with AC in patients with chronic AI.

Methods: A total of 423 patients with AI (primary AI, n = 221; secondary AI, n = 202) were prospectively followed up for 2 years.

Timelines in the management of adrenal crisis - targets, limits and reality.

Objective: To evaluate current management timelines in adrenal crisis (AC) and to establish time targets and time limits for emergency treatment.

Design/patients: Patients from a prospective study who had reported an AC (n = 46) were contacted and asked about management of their AC. A survey among 24 European endocrinologists collected expert recommendations concerning time targets and time limits for contact-arrival time of emergency health professionals and presentation of emergency card-glucocorticoid (GC) injection time.