Publications by authors named "Christina So"
Membrane contact sites (MCSs) are sites of close apposition between two organelles used to exchange ions, lipids, and information. Cells respond to changing environmental or developmental conditions by modulating the number, extent, or duration of MCSs. Because of their small size and dynamic nature, tools to study the dynamics of MCSs in live cells have been limited.
View Article and Find Full Text PDFCells adjust their metabolism by remodeling membrane contact sites that channel metabolites to different fates. Lipid droplet (LD)-mitochondria contacts change in response to fasting, cold exposure, and exercise. However, their function and mechanism of formation have remained controversial.
View Article and Find Full Text PDFOocyte Development and Quality in Young and Old Mice following Exposure to Atrazine.
Environ Health Perspect
November 2022
Background: Egg development has unique features that render it vulnerable to environmental perturbation. The herbicide atrazine is an endocrine disruptor shown to have detrimental effects on reproduction across several vertebrate species.
Objectives: This study was designed to determine whether exposure to low levels of atrazine impairs meiosis in female mammals, using a mouse model; in particular, the study's researchers sought to determine whether and how the fidelity of oocyte chromosome segregation may be affected and whether aging-related aneuploidy is exacerbated.
Article Synopsis
- - This study examined the outcomes of 940 critically ill patients with tuberculosis (TB) admitted to ICUs in Hong Kong over an 11-year period, finding high mortality rates of 24.7% in ICUs and 41.1% in hospitals, with a significant portion of ICU deaths occurring in patients who did not receive TB treatment.
- - Researchers used methods like generalized linear modeling and analyzed mortality trends, concluding that delays in TB treatment are linked to increased hospital mortality, and they noted that diagnostic methods like MTB PCR were underutilized.
- - The results suggest that despite TB being preventable and treatable, survival rates for ICU patients have not improved, emphasizing the need for quicker diagnoses and treatment to enhance patient
Objective: To report the first eight cases of critically ill patients with coronavirus disease 2019 (COVID-19) in Hong Kong, describing the treatments and supportive care they received and their 28-day outcomes.
Design: Multicentre retrospective observational cohort study.
Setting: Three multidisciplinary intensive care units (ICUs) in Hong Kong.
Objective: Numerous studies have identified an association between headache disorders and vestibular symptoms, such as dizziness, vertigo, and motion sensitivity. Using bipolar, binaural galvanic vestibular stimulation (GVS), our objectives were to (1) determine the degree of vestibular sensitivity in borderline headache sufferers, and (2) characterize the postural response to vestibular perturbation in these individuals.
Methods: Fourteen volunteers participated in this study: 8 individuals with chronic headache (6 with migraine and 2 with tension type headache (TTH)), and 6 healthy control subjects.