Publications by authors named "Christina Schwandt"
Article Synopsis
- The study investigated the impact of the C-344T polymorphism in the aldosterone synthase gene on focal segmental glomerulosclerosis (FSGS) in patients.
- Researchers followed 81 patients with FSGS and found significant differences in allele frequencies between patients and healthy controls, as well as correlations between the C-allele and worse kidney function.
- The findings suggest that this genetic polymorphism could be a risk factor for FSGS progression and may provide insights into disease severity and outcomes.
Aim: In the past years, aldosterone has been identified as an important mediator of renal injury. In this study, we evaluated the influence of C-344T polymorphism of aldosterone synthase gene, associated with serum aldosterone levels and the development of arterial hypertension, on IgA nephropathy (IgAN).
Methods: We studied n = 143 patients with biopsy-proven IgAN followed up for 7.
Article Synopsis
- This study examines the role of interleukin-6 (IL-6) gene G-174C polymorphism in affecting the risk of coronary artery disease (CAD), cardiovascular events, and mortality in patients undergoing chronic dialysis.
- It involved 463 chronic dialysis patients, revealing that those with the CC genotype had significantly poorer survival rates and faced more cardiovascular events compared to other genotypes.
- While the IL-6 gene polymorphism impacted patient outcomes, it did not influence the onset or progression of CAD itself, nor did it show differences in inflammatory markers like CRP and fibrinogen among genotypes.
Background: The G-1082A polymorphism of the interleukin-10 (IL-10) gene has been associated with modified gene expression and the progression of primary IgA nephropathy (IgAN). In the present study, we evaluated its influence on recurrent IgAN after renal transplantation.
Methods: We studied 103 patients who suffered from IgAN and underwent renal transplantation, followed up for 5.
Background: Uncontrolled mesangial cell (MC) proliferation within the context of glomerular disease contributes to the development of glomerulosclerosis. Mesangial autocrine growth factor stimulation has been described as a pathogenic factor. We investigated the effects of mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), on proliferation factors of cultured rat MCs.
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