Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs.

Background & Aim: Primary hepatic angiosarcoma is a rare tumor with poor prognosis. The aim of this study was to generate a new angiosarcoma model to improve research on hepatic angiosarcoma.

Methods: Pigs sus scrofa were treated with different regimens of diethylnitrosamine (DENA).

Hepatocellular Carcinoma and Nuclear Paraspeckles: Induction in Chemoresistance and Prediction for Poor Survival.

Background/aims: Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related deaths worldwide, not least due to its high chemoresistance. The long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1), localised in nuclear paraspeckles, has been shown to enhance chemoresistance in several cancer types. Since data on NEAT1 in HCC chemosensitivity are completely lacking and chemoresistance is linked to poor prognosis, we aimed to study NEAT1 expression in HCC chemoresistance and its link to HCC prognosis.

The long non-coding RNA suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma.

The long non-coding RNA (lncRNA) represents a maternally expressed and epigenetically regulated imprinted gene product and is discussed to have either tumor-promoting or tumor-suppressive actions. Recently, was shown to be regulated under inflammatory conditions. Therefore, aim of this study was to determine the function of in hepatocellular carcinoma (HCC), an inflammation-associated type of tumor.