Publications by authors named "Christina S Linnebacher"
Despite significant advances in diagnostic techniques and treatment approaches, the prognosis of pancreatic ductal adenocarcinoma (PDAC) is still poor. Previous studies have reported that S-phase kinase-associated protein 2 (SKP2), a subunit of the SCF E3 ubiquitin ligase complex, is engaged in the malignant biological behavior of some tumor entities. However, SKP2 has not been fully investigated in PDAC.
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- Robust cancer cell models, especially patient-derived models, are crucial for effective drug development and precision oncology research, as they maintain more genetic and phenotypic similarities to original tumors compared to conventional lines.
- Three distinct patient-derived cell lines (PDCs) representing different types of non-small cell lung cancer (NSCLC) were created and thoroughly analyzed for their characteristics, including growth patterns, genetic makeup, and responses to standard chemotherapy treatments.
- The established PDC models preserved the genetic and molecular traits of the original tumors, showed key mutations, and did not exhibit pre-existing resistance to therapies, indicating their potential usefulness in cancer research and treatment development.
Background: Previous studies have described that the gene is involved in the occurrence and development of various tumor entities. However, little is known about its expression and relevance in stomach adenocarcinoma (STAD). The aim of this study was to bioinformatically analyze the role of in STAD, followed by patient tissue sample analyses.
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