Publications by authors named "Christina S Karali"
Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary leukemia, advanced cancers with a poor prognosis and high symptom burden. Currently, it remains difficult to predict progression, and therapies that reliably prevent or reverse fibrosis are lacking.
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- The study investigates the role of brain pericytes in the microvascular no-reflow phenomenon after reopening an artery during ischemic stroke.
- It finds that mTOR inhibition via rapamycin reduces pericyte contraction during simulated ischemia, though it doesn't significantly affect cell survival.
- In a mouse model, rapamycin improves capillary diameter and increases the number of open capillaries following arterial recanalization, suggesting it could be a helpful treatment to enhance blood flow in the brain after a stroke.
Article Synopsis
- Researchers developed a method to create organoids from induced pluripotent stem cells that mimic human bone marrow, which is crucial for studying blood formation and cancers.
- These 3D organoids replicate essential components of bone marrow and support the growth of cancer cells from patients, which are typically hard to maintain in lab settings.
- This innovative platform helps investigate blood cancers and their interactions within the bone marrow environment, aiding in the search for new treatments.
Background: Somatostatin receptor-2 (SSTR2) is expressed on cell surface of neuroendocrine neoplasias; its presence is exploited for the delivery of peptide receptor radionuclide therapy (PRRT). Patients with no or low expression of SSTR2 are not candidates for PRRT. SSTR2 promotor undergoes epigenetic modification, known to regulate gene expression.
View Article and Find Full Text PDFA novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models.
J Cereb Blood Flow Metab
July 2021
Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molecular level. Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. The aim of this study, therefore, was to develop a novel molecular MRI contrast agent, by conjugating anti-ALCAM antibodies to microparticles of iron oxide (MPIO), for detection of endothelial ALCAM expression .
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