Publications by authors named "Christina S E Carroll"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are a groundbreaking cancer treatment, but only about 30% of patients see lasting results, indicating variability in responses to therapy.
- The study uses fine-needle aspiration (a nonterminal method) to collect data on immune cells from mouse cancer models, allowing researchers to analyze how immune response correlates with treatment outcomes.
- Results show that specific T cell populations increased significantly in mice that responded well to anti-CTLA4 therapy, providing insights into why different genetically similar mice experience different therapeutic responses.
Simple and effective bacterial-based intratumoral cancer immunotherapy.
J Immunother Cancer
September 2021
Article Synopsis
- Researchers tested a slow-release emulsion of killed mycobacteria (CFA) for treating tumors in mice, dogs, horses, and human cancer patients, analyzing its effects on survival and immune response.
- * In preclinical trials, significant tumor regression and extended survival were observed across all species, with immune cell analysis indicating that early neutrophil infiltration predicted treatment success.
- * The treatment was well tolerated in human patients, and CT scans showed tumor regression, particularly in a late-stage renal cancer patient.
This paper describes a novel method for following the changes in mouse tumour-infiltrating immune cell populations by repeated sampling of tumours by fine needle aspiration (FNA), followed by flow cytometry. Using this technique we were able to collect samples from P815 mouse mastocytomas, and identify and enumerate six tumour-infiltrating immune cell types at multiple time points for each mouse. We demonstrate good agreement between cell percentages obtained from FNA samples and matched whole tumour digests (WTDs).
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