Publications by authors named "Christina R Bates"
Article Synopsis
- Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a serious genetic disorder caused by mutations in the LAMA2 gene, leading to muscle loss and inflammation without any current cure.
- Researchers created a new immunocompromised mouse model of LAMA2-CMD to examine how the immune system impacts muscle disease and to test the effectiveness of human laminin-111 and laminin-211 as protein replacement therapies.
- The study found that while the new mouse model showed some differences in muscle regeneration, both human laminin-111 and laminin-211 improved muscle function and pathology, indicating their potential as effective treatments for LAMA2-CMD.
Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain. The α2-chain is a major component of the laminin-211 and laminin-221 isoforms, the predominant laminin isoforms in healthy adult skeletal muscle.
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