Characterization of the bone-metal implant interface by Digital Volume Correlation of in-situ loading using neutron tomography.

Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening.

Neutron tomographic imaging of bone-implant interface: Comparison with X-ray tomography.

Metal implants, in e.g. joint replacements, are generally considered to be a success.

The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect.

Long bone defects can be managed by the induced membrane technique together with autologous bone graft. However, graft harvest is associated with donor site morbidity. This study investigates if a tricalcium phosphate hydroxyapatite scaffold can be used alone or in combination with bone active drugs to improve healing.

Characterizing the composition of bone formed during fracture healing using scanning electron microscopy techniques.

About 5-10% of all bone fractures suffer from delayed healing, which may lead to non-union. Bone morphogenetic proteins (BMPs) can be used to induce differentiation of osteoblasts and enhance the formation of the bony callus, and bisphosphonates help to retain the newly formed callus. The aim of this study was to investigate if scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) can identify differences in the mineral composition of the newly formed bone compared to cortical bone from a non-fractured control.