Reduction of [Ga]Ga-DOTA-TATE injected activity for digital PET/MR in comparison with analogue PET/CT.

Background: New digital detectors and block-sequential regularized expectation maximization (BSREM) reconstruction algorithm improve positron emission tomography (PET)/magnetic resonance (MR) image quality. The impact on image quality may differ from analogue PET/computed tomography (CT) protocol. The aim of this study is to determine the potential reduction of injected [Ga]Ga-DOTA-TATE activity for digital PET/MR with BSREM reconstruction while maintaining at least equal image quality compared to the current analogue PET/CT protocol.

A dedicated paediatric [F]FDG PET/CT dosage regimen.

Background: The role of 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiation dose as low as reasonably achievable and reduce the risk of radiation-induced carcinogenesis. The aim of this study is to investigate the relation between patient-dependent parameters and [F]FDG PET image quality in order to propose a dedicated paediatric dose regimen.

Standardized image quality for Ga-DOTA-TATE PET/CT.

Background: Positron emission tomography (PET) imaging with Gallium labeled somatostatin analogues (Ga-DOTA-SSA) plays a key role in neuroendocrine tumor management. The impact of patient size on PET image quality is not well known for PET imaging with Ga-DOTA-SSA. The aim of this study is to propose a dose regimen based on patient size that optimizes image quality and yields sufficient image quality for diagnosis.