Predictive factors for fertility preservation in pediatric and adolescent girls with planned gonadotoxic treatment.

Purpose: To characterize female pediatric and adolescent patients seen for fertility preservation consultation at an academic medical center and to describe the association between demographic or clinical factors and the use of fertility preservation treatment (FPT).

Methods: This is a retrospective chart analysis of female pediatric and adolescent patients seen for fertility preservation consultation at an academic fertility center over a 14-year period from 2005 to 2019.

Results: One hundred six females aged 3-21 years were seen for fertility preservation consultation with a mean age of 16.

Mechanical stiffness augments ligand-dependent progesterone receptor B activation via MEK 1/2 and Rho/ROCK-dependent signaling pathways in uterine fibroid cells.

Objective: To test whether mechanical substrate stiffness would influence progesterone receptor B (PRB) signaling in fibroid cells. Uterine fibroids feature an excessive extracellular matrix, increased stiffness, and altered mechanical signaling. Fibroid growth is stimulated by progestins and opposed by anti-progestins, but a functional interaction between progesterone action and mechanical signaling has not been evaluated.

Efficacy of progestin-only treatment for the management of menopausal symptoms: a systematic review.

Importance: Menopause is associated with bothersome symptoms for many women, including mood changes, hot flushes, sleep problems, and fatigue. Progesterone is commonly prescribed in combination with estrogen therapy. Although monotherapy with progestins has been used as treatment of menopausal symptoms in women with contraindications to estrogens, the optimal route, and dosage of progestin monotherapy has not been established.

Conservatively treated endometrial intraepithelial neoplasia/cancer: Risk of intrauterine synechiae.

Introduction: To determine whether progestin type or number of dilation and curettage procedures (D&Cs) were associated with intrauterine synechiae (IS) or pregnancy outcomes in patients conservatively treated for endometrial intraepithelial neoplasia (EIN) or endometrial cancer (EC).

Materials And Methods: We evaluated patients conservatively treated for EIN or EC from 2000 to 2017 at an academic center. IS were identified hysteroscopically.

Understanding Patients' Knowledge and Feelings Regarding Their Cryopreserved Ovarian Tissue: A Qualitative Interviewing Study.

For prepubertal girls, or when gonadotoxic treatment is urgent, ovarian tissue cryopreservation (OTC) represents the only option for fertility preservation. We sought to determine patients' knowledge and feelings about their cryopreserved ovarian tissue. We conducted qualitative interviews with women aged 18 years or older who underwent OTC at our academic fertility center between 2006 and 2017.

Navigating the body of literature assessing BRCA1/2 mutations and markers of ovarian function: a systematic review and meta-analysis.

Purpose: Twelve percent of women in the USA will develop invasive breast cancer in their lifetime, and that risk increases to 80% if they carry a BRCA1 or BRCA2 mutation. BRCA1/2 mutations are thought to potentially affect ovarian reserve and/or fertility.

Methods: PubMed and PubMed Central were searched for publications on ovarian reserve-related outcomes (i.

Advanced ovarian cancer treated in pregnancy and detected by cell-free DNA aneuploidy screening.

•Abnormal cell free DNA results may indicate occult maternal malignancy.•Cesarean-cytoreductive surgery is feasible even with significant disease burden.•Carboplatin/paclitaxel is first line for epithelial ovarian cancer in pregnancy.