Publications by authors named "Christina M Gebauer"
Article Synopsis
- * Paraneoplastic neurologic disorders are immune-mediated diseases that occur alongside certain cancers, where the immune system mistakenly attacks the nervous system due to tumor-associated antigens.
- * Research using a mouse model reveals that CTLA4 blockade can trigger specific T cell activity that leads to neuroinflammation and damage to brain cells, especially in patients with gynecological or neuroectodermal cancers, indicating a need for careful monitoring in these cases.
Paraneoplastic neurological disorders (PNDs) are syndromes that develop in cancer patients when an efficient antitumor immune response, directed against antigens expressed by both malignant cells and healthy neurons, damages the nervous system. Herein, we analyze existing data on the mechanisms of loss of self tolerance and nervous tissue damage that underpin one of the most frequent PNDs, the anti-Hu syndrome. In addition, we discuss future directions and propose potential strategies aimed at blocking deleterious encephalitogenic immune responses while preserving the antineoplastic potential of treatment.
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