Tunable and Photoactivatable Mimics of Calicheamicin γ for DNA Cleavage.

Calicheamicin γ and related natural products are renowned for their potency in DNA cleavage, serving as the warheads in commercial ADCs used for treating leukemia. Their mechanism of action involves the formation of aryl radicals, which abstract hydrogen atoms from nucleic acids. However, the complex strained enediyne structure of calicheamicin γ presents significant challenges in synthesis, resulting in high production costs and limited structural and activity modularity for tuning the therapeutic window.

Implementing a Doping Approach for Poly(methyl methacrylate) Recycling in a Circular Economy.

To mitigate pollution by plastic waste, it is paramount to develop polymers with efficient recyclability while retaining desirable physical properties. A recyclable poly(methyl methacrylate) (PMMA) is synthesized by incorporating a minimal amount of an α-methylstyrene (AMS) analogue into the polymer structure. This P(MMA--AMS) copolymer preserves the essential mechanical strength and optical clarity of PMMA, vital for its wide-ranging applications in various commercial and high-tech industries.