Publications by authors named "Christina L Elling"
Article Synopsis
- Obstructive sleep-disordered breathing (oSDB) is becoming more common worldwide, especially in children, and it can lead to various health issues that impact quality of life.
- Researchers studied the tonsils of children with oSDB to identify specific genes that may serve as biomarkers, focusing on the presence of Epstein-Barr virus (EBV) and the use of CPAP treatment.
- Nineteen specific genes were found to be dysregulated in the tonsils, suggesting they could help assess the severity and related health problems of oSDB, and that their levels may be influenced by EBV infection.
The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media.
Int J Pediatr Otorhinolaryngol
June 2024
Background: Inflammation and infection of the middle ear, known as otitis media (OM), is a leading cause of hearing loss and the most frequently diagnosed disease in children worldwide. Traditionally, mouse models for OM rely on inducing acute infection through inoculation of the middle ear, e.g.
View Article and Find Full Text PDFOtitis media (OM) is defined as middle ear (ME) inflammation that is usually due to infection. Globally, OM is a leading cause of hearing loss and is the most frequently diagnosed disease in young children. For OM, pediatric patients with Down syndrome (DS) demonstrate higher incidence rates, greater severity, and poorer outcomes.
View Article and Find Full Text PDFOtitis media (OM) is a leading cause of childhood hearing loss. Variants in , which encodes alpha-(1,2)-fucosyltransferase, were identified to increase susceptibility to OM, potentially through shifts in the middle ear (ME) or nasopharyngeal (NP) microbiotas as mediated by transcriptional changes. Greater knowledge of differences in relative abundance of otopathogens in carriers of pathogenic variants can help determine risk for OM in patients.
View Article and Find Full Text PDFArticle Synopsis
- Otitis media (OM) is a common ear infection in kids that can lead to problems with hearing and speaking.
- Researchers found new genetic changes in a gene called CDHR3 that may make some kids more likely to get OM.
- These findings help us understand how CDHR3 plays an important role in the risk of getting ear infections in children.
Zika virus (ZIKV) is an emerging flavivirus responsible for a major epidemic in the Americas beginning in 2015. ZIKV associated with maternal infection can lead to neurological disorders in newborns, including microcephaly. Although there is an abundance of research examining the neurotropism of ZIKV, we still do not completely understand the mechanism by which ZIKV targets neural cells or how to limit neural cell infection.
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