Publications by authors named "Christina Kosanovic"
Article Synopsis
- Hispanic/Latino populations, particularly Puerto Ricans, are underrepresented in Alzheimer Disease (AD) genetics research, prompting a study to identify new AD risk loci in this group.
- The study involved Whole Genome Sequencing and analyzed data from 648 Puerto Ricans, adjusting for various factors to ensure accurate results and inferring local ancestry.
- Results revealed a suggestive AD risk locus on chromosome 12 and replicated several known AD genetic loci, emphasizing the need for including diverse populations in genetic studies to improve understanding of AD.
GATAD2B (GATA zinc finger domain containing 2B) variants are associated with the neurodevelopmental syndrome GAND, characterized by intellectual disability (ID), infantile hypotonia, apraxia of speech, epilepsy, macrocephaly and distinct facial features. GATAD2B encodes for a subunit of the Nucleosome Remodeling and Histone Deacetylase (NuRD) complex. NuRD controls transcriptional programs critical for proper neurodevelopment by coupling histone deacetylase with ATP-dependent chromatin remodeling activity.
View Article and Find Full Text PDFThe venous system has been historically understudied despite its critical roles in blood distribution, heart function, and systemic immunity. This study dissects the microanatomy of upper arm veins at the single cell level, and how it relates to wall structure, remodeling processes, and inflammatory responses to injury. We applied single-cell RNA sequencing to 4 non-diseased human veins (3 basilic, 1 cephalic) obtained from organ donors, followed by bioinformatic and histological analyses.
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