Publications by authors named "Christina K Mogensen"
Article Synopsis
- Chronic kidney disease (CKD) leads to uremia, characterized by increased kidney fibrosis and loss of function, raising the risk of atherosclerosis and cardiovascular death.
- The study investigates the effects of liraglutide, a GLP-1 analogue known for improving glucose control in diabetes, on kidney fibrosis and atherosclerosis in uremic mice.
- Results indicate liraglutide treatment significantly reduced atherosclerosis and kidney inflammation, but did not affect fibrosis markers or kidney histology in the model used.
Article Synopsis
- Macrophages can polarize into different types, mainly pro-inflammatory M1-like and re-modeling M2-like, and this study compared the characteristics of peritoneal macrophages (PEMs) and bone marrow-derived macrophages (BMDMs) against aortic macrophages from a specific mouse model (ApoE-/-).
- Both PEMs and BMDMs accumulate similar amounts of oxidized LDL, but BMDMs typically have a more prominent M2-like profile, showing different responses to cholesterol loading, indicating that they have distinct roles in inflammation and lipid handling.
- In advanced atherosclerosis, a significant increase in M2-like macrophages was observed in the aorta, but with
