Quantification of liver proton-density fat fraction in 7.1T preclinical MR systems: Impact of the fitting technique.

Purpose: To investigate the feasibility of estimating the proton-density fat fraction (PDFF) using a 7.1T magnetic resonance imaging (MRI) system and to compare the accuracy of liver fat quantification using different fitting approaches.

Materials And Methods: Fourteen leptin-deficient ob/ob mice and eight intact controls were examined in a 7.

T1 bias in chemical shift-encoded liver fat-fraction: role of the flip angle.

Purpose: To investigate flip angle (FA)-dependent T1 bias in chemical shift-encoded fat-fraction (FF) and to evaluate a strategy for correcting this bias to achieve accurate MRI-based estimates of liver fat with optimized signal-to-noise ratio (SNR).

Materials And Methods: Thirty-three obese patients, 14 men/19 women, aged 57.3 ± 13.