A demographic comparison and characterization of pediatric poisoning before and after the emergence of COVID-19.

Background: To compare relative rates of pediatric poisoning before and after COVID-19, including by demographic and urban-rural status, and by agent identified, using data from one university healthcare system and children's hospital.

Methods: Using retrospective, cross sectional design from deidentified healthcare claims data, we extracted all encounters with the ICD-10-CM for Poisoning by, Adverse effects of, and Underdosing of drugs, medicants and biological substances (T36-T50) and grouped the encounters as those after state mandates regulating activity came into effect (Post-COVID-19 (3/17/2020-3/18/2021)) Pre-COVID-19 (3/18/2019-3/17/2020). We then compared poisoning agent, age at the time of the encounter, recorded sex, race, ethnicity, rural/urban residence, and visit type using Mann-Whitney U test, chi-square test of association, incidence rates and incident rate ratios between the time periods.

Peak occipital alpha frequency mediates the relationship between sporting expertise and multiple object tracking performance.

Background: Multiple object tracking (MOT) is often used as a lab-based paradigm for investigating goal-driven attention as an indicator for "real-world" attention in tasks such as sport. When exploring MOT performance in the context of sporting expertise, we typically observe that individuals with sporting expertise outperform non-sporting individuals. There are a number of general explanations for performance differences such as cognitive transfer effects; however, the potential neurophysiological mechanisms explaining the relationship between sporting expertise and performance differences in MOT are not clear.

Employing non-canonical amino acids towards the immobilization of a hyperthermophilic enzyme to increase protein stability.

A carboxylesterase derived from P1 was immobilized onto an epoxy-activated Sepharose resin non-canonical amino acids. The immobilized enzyme exhibited heightened performance in organic solvents, recyclability, and stability at room temperature for over two years. The incorporation of a non-canonical amino acid afforded a high degree of control over the bioorthogonal immobilization reaction.

A case-control study comparing rates and diagnoses of hospital readmission in infants affected by neonatal abstinence syndrome.

Objective: Rates of neonatal abstinence syndrome/neonatal opioid withdrawal syndrome (NAS/NOWS), a withdrawal syndrome from opioids and other substances resulting from intrauterine exposure, have been increasing exponentially in the U.S. To improve health outcomes, it is important to understand population health risks, including rehospitalization and related diagnoses, using current data.

Protein Modification Employing Non-Canonical Amino Acids to Prepare SUMOylation Detecting Bioconjugates.

Protein modification with non-canonical amino acids (ncAAs) represents a useful technology to afford homogenous samples of bioconjugates with site-specific modification. This technique can be directly applied to the detection of aberrant SUMOylation patterns, which are often indicative of disease states. Modified SUMO-trapping proteins, consisting of a catalytically inactive ULP1 fragment (UTAG) fused to the maltose-binding protein MBP, are useful reagents for the binding and labeling of SUMOylated proteins.

Tracking multiple fish.

Although the Multiple Object Tracking (MOT) task is a widely used experimental method for studying divided attention, tracking objects in the real world usually looks different. For example, in the real world, objects are usually clearly distinguishable from each other and also possess different movement patterns. One such case is tracking groups of creatures, such as tracking fish in an aquarium.

Neurophysiological markers of prospective memory and working memory in typical ageing and mild cognitive impairment.

Objective: Prospective memory (PM) -the memory of delayed intentions- is impacted by age-related cognitive decline. The current event-related potential study investigates neural mechanisms underpinning typical and atypical (Mild Cognitive Impairment, MCI) age-related decline in PM.

Methods: Young adults (YA, n = 30, age = 24.

The Multiple Object Avoidance (MOA) task measures attention for action: Evidence from driving and sport.

Performance in everyday tasks, such as driving and sport, requires allocation of attention to task-relevant information and the ability to inhibit task-irrelevant information. Yet there are individual differences in this attentional function ability. This research investigates a novel task for measuring attention for action, called the Multiple Object Avoidance task (MOA), in its relation to the everyday tasks of driving and sport.

Motion disrupts dynamic visual search for an orientation change.

Visual search in dynamic environments, for example lifeguarding or CCTV monitoring, has several fundamentally different properties to standard visual search tasks. The visual environment is constantly moving, a range of items could become targets and the task is to search for a certain event. We developed a novel task in which participants were required to search static and moving displays for an orientation change thus capturing components of visual search, multiple object tracking and change detection paradigms.

Age differences in resting state EEG and their relation to eye movements and cognitive performance.

Prior research has focused on EEG differences across age or EEG differences across cognitive tasks/eye tracking. There are few studies linking age differences in EEG to age differences in behavioural performance which is necessary to establish how neuroactivity corresponds to successful and impaired ageing. Eighty-six healthy participants completed a battery of cognitive tests and eye-tracking measures.

Wood product carbon substitution benefits: a critical review of assumptions.

Background: There are high estimates of the potential climate change mitigation opportunity of using wood products. A significant part of those estimates depends on long-lived wood products in the construction sector replacing concrete, steel, and other non-renewable goods. Often the climate change mitigation benefits of this substitution are presented and quantified in the form of displacement factors.

Search for a distressed swimmer in a dynamic, real-world environment.

Visual search is increasingly being explored in dynamic, real-world environments. This includes swimming pools, where lifeguards have shown superior drowning detection in simulated environments. Here, we explored if lifeguard superiority is observed in real-life scenes of a busy swimming pool.

Audio-visual integration in noise: Influence of auditory and visual stimulus degradation on eye movements and perception of the McGurk effect.

Seeing a talker's face can aid audiovisual (AV) integration when speech is presented in noise. However, few studies have simultaneously manipulated auditory and visual degradation. We aimed to establish how degrading the auditory and visual signal affected AV integration.

Visual spatial attention and spatial working memory do not draw on shared capacity-limited core processes.

The extent to which similar capacity limits in visual attention and visual working memory indicate a common shared underlying mechanism is currently still debated. In the spatial domain, the multiple object tracking (MOT) task has been used to assess the relationship between spatial attention and spatial working memory though existing results have been inconclusive. In three dual task experiments, we examined the extent of interference between attention to spatial positions and memory for spatial positions.

Low-Frequency Repetitive Transcranial Magnetic Stimulation to Right Parietal Cortex Disrupts Perception of Briefly Presented Stimuli.

Right parietal cortex has recently been linked to the temporal resolution of attention. We therefore sought to investigate whether disruption to right parietal cortex would affect attention to visual stimuli presented for brief durations. Participants performed a visual discrimination task before and after 10 minutes repetitive transcranial magnetic stimulation (1 Hz) to right or central parietal cortex as well as 20 minutes after the second block of trials.

Goal-directed unequal attention allocation during multiple object tracking.

In standard multiple object tracking (MOT) tasks the relative importance of the targets being tracked is equal. This is atypical of everyday situations in which an individual may need to prioritize one target relative to another and so allocate attention unequally. We report three experiments that examined whether participants could unequally split attention using a modified MOT task in which target priority was manipulated.

Reduction in lower-alpha power during Ganzfeld flicker stimulation is associated with the production of imagery and trait positive schizotypy.

Light-flicker Ganzfeld (LFG) induces a lower to upper-alpha frequency shift. However, it is unclear how this neurophysiological response might relate to LFG-induced pseudo-hallucinatory phenomena. It is also unknown whether emotional states (e.

Team ball sport participation is associated with performance in two sustained visual attention tasks: Position monitoring and target identification in rapid serial visual presentation streams.

We investigated the relationship between participation in team ball sports and performance in two sustained spatiotemporal attention tasks-a position monitoring variant of the multiple object tracking (MOT) task and target identification in the rapid serial visual presentation (RSVP) task. Thirty participants were asked about the frequency of their participation in team ball sports and undertook both the MOT task and RSVP task. In the MOT task, participants viewed an array of eight discs as they moved unpredictably for 3-8s before disappearing.

Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study.

Acute kidney injury (AKI) after severe burns is historically associated with a high mortality. Over the past two decades, various modes of renal replacement therapy (RRT) have been used in this population. The purpose of this multicenter study was to evaluate demographic, treatment, and outcomes data among severe burn patients treated with RRT collectively at various burn centers around the United States.

Engagement of the motor system in position monitoring: reduced distractor suppression and effects of internal representation quality on motor kinematics.

The position monitoring task is a measure of divided spatial attention in which participants track the changing positions of one or more objects, attempting to represent positions with as much precision as possible. Typically precision of representations declines with each target object added to participants' attention load. Since the motor system requires precise representations of changing target positions, we investigated whether position monitoring would be facilitated by increasing engagement of the motor system.

Slower resting alpha frequency is associated with superior localisation of moving targets.

We examined the neurophysiological underpinnings of individual differences in the ability to maintain up-to-date representations of the positions of moving objects. In two experiments similar to the multiple object tracking (MOT) task, we asked observers to monitor continuously one or several targets as they moved unpredictably for a semi-random period. After all objects disappeared, observers were immediately prompted to report the perceived final position of one queried target.

Sustained attention to objects' motion sharpens position representations: Attention to changing position and attention to motion are distinct.

In tasks where people monitor moving objects, such the multiple object tracking task (MOT), observers attempt to keep track of targets as they move amongst distracters. The literature is mixed as to whether observers make use of motion information to facilitate performance. We sought to address this by two means: first by superimposing arrows on objects which varied in their informativeness about motion direction and second by asking observers to attend to motion direction.

Utilization of alkyne bioconjugations to modulate protein function.

The ability to introduce or modify protein function has widespread application to multiple scientific disciplines. The introduction of unique unnatural amino acids represents an excellent mechanism to incorporate new functionality; however, this approach is limited by ability of the translational machinery to recognize and incorporate the chemical moiety. To overcome this potential limitation, we aimed to exploit the functionality of existing unnatural amino acids to perform bioorthogonal reactions to introduce the desired protein modification, altering its function.