Publications by authors named "Christina Hoffman"

Objective: This matched control study was conducted to evaluate the effect of targeted short-form messages or continuing medical education (CME) on fluoroquinolone prescribing among high prescribers.

Methods: A total of 11,774 Medscape healthcare provider (HCP) members prescribing high volumes of fluoroquinolones were randomized into three segments to receive one of three unique targeted short-form messages, each delivered via email, web alerts, and mobile alerts. Some HCPs receiving targeted short-form messages also participated in CME on fluoroquinolone prescribing.

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Single-crystal time-of-flight neutron diffraction has provided atomic resolution of H atoms of HO molecules and hydroxyl groups, as well as Li cations in the uranyl peroxide nanocluster U. Solid-state magic-angle-spinning nuclear magnetic resonance (MAS NMR) spectroscopy was used to confirm the dynamics of these constituents, revealing the transportation of Li atoms and HO through cluster walls. H atoms of hydroxyl units that are located on the cluster surface are involved in the transfer of HO and Li cations from inside to outside and vice versa.

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Article Synopsis
  • Understanding diabetes medication adherence is essential for effective management and to prevent complications.
  • A survey conducted on WebMD revealed that patient-reported adherence is linked to their behaviors and influences, such as the receipt of information from healthcare providers.
  • Patients who engage with their healthcare providers tend to adhere better to their medication regimens, highlighting the need for effective patient education by clinicians.
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The electron densities in two analogous dimetallic transition metal compounds, namely, [M2(μ-OH2)((t)BuCOO)4((t)BuCOOH)2(C5H5N)2] (M = Co(1), Ni(2)), were determined from combined X-ray and neutron single-crystal diffraction at 100 K. Excellent correspondence between the thermal parameters from X- and N-derived atomic displacement parameters is found, indicating high-quality X-ray data and a successful separation of thermal and electronic effects. Topological analysis of electron densities derived from high-resolution X-ray diffraction, as well as density functional theory calculations, shows no direct metal-metal bonding in either compound, while the total energy density at the bond critical points suggests stronger metal-oxygen interactions for the Ni system, in correspondence with its shorter bond distances.

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The hydration of the coenzyme cob(II)alamin has been studied using high-resolution monochromatic neutron crystallographic data collected at room temperature to a resolution of 0.92 Å on the original D19 diffractometer with a prototype 4° × 64° detector at the high-flux reactor neutron source run by the Institute Laue-Langevin. The resulting structure provides hydrogen-bonding parameters for the hydration of biomacromolecules to unprecedented accuracy.

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