Publications by authors named "Christina Gerets"
The effect of xenon on isoflurane protection against experimental myocardial infarction.
J Cardiothorac Vasc Anesth
October 2009
Objectives: To investigate if the protective effects of xenon and isoflurane against myocardial ischemia-reperfusion damage would be additive.
Design: A prospective, randomized laboratory investigation.
Setting: An animal laboratory of a university hospital.
Background: Volatile anesthetics protect the myocardium from ischemia reperfusion damage. Our hypothesis for this study was that xenon reduces the size of myocardial infarction similar in extent to the reduction associated with ischemic preconditioning.
Methods: Thirty-six pigs weighing 30-35 kg were anesthetized with thiopental and then randomized into four groups: control (myocardial ischemia only), ischemic preconditioning (five 5-min episodes of intermittent myocardial ischemia), xenon preconditioning (three 10-min exposures to xenon 70% followed by myocardial ischemia), and xenon anesthesia (xenon 70%, continued before and after myocardial ischemia).