Publications by authors named "Christina Fillmore"
Aims: Lung congestion in patients with heart failure (HF) has traditionally been treated using interventions that reduce pulmonary capillary hydrostatic pressure. The transient receptor potential vanilloid 4 (TRPV4) channel regulates fluid transit across the pulmonary capillary-interface, and represents a novel target to reduce lung water, independent of pulmonary capillary hypertension. This pilot study examined the safety and potential efficacy of TRPV4 blockade as a novel treatment for HF.
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- Daprodustat, a drug that inhibits prolyl hydroxylases, helps prevent the breakdown of a key protein that promotes healing and gene expression related to hypoxia in the body.
- A study tested a topical version of daprodustat's safety and effectiveness on healthy volunteers and diabetic foot ulcer patients, showing weak improvements in wound healing but questionable efficacy due to small sample sizes.
- Overall, daprodustat was safe and well-tolerated with limited systemic absorption, indicating that further research with longer treatment periods is necessary to accurately assess its impact on diabetic foot ulcers.
Background: The availability of marijuana products is becoming increasingly prevalent across the United States (US), many states are allowing for the production, processing, and retailing of these products for medical and/or recreational use. The purpose of this study is to: (1) examine the spatial patterning of marijuana licenses, and (2) examine the impact of alcohol outlets in addition to other neighborhood characteristics on marijuana licenses within the state of Washington.
Methods: This cross-sectional observational study examined 1458 census tracts in Washington state from 2017, using marijuana and alcohol data from the Washington State Liquor and Cannabis Board as well as neighborhood characteristics data from the American Community Survey 2011-2015 5-year estimates.