Publications by authors named "Christina Daugaard Lyngholm"
Article Synopsis
- - Marfan syndrome (MFS) is a complex disorder linked to connective tissue that presents in various ways and is diagnosed using the Ghent criteria, which require clinical and genetic evidence.
- - The condition is mainly caused by mutations in the FBN1 gene that disrupt the fibrillin-1 protein's structure, specifically by affecting cysteine residues that are critical for its function.
- - A recent study identified a specific FBN1 variant that introduces cysteine but was found in individuals without MFS, prompting a re-evaluation of genetic understandings of the disorder and highlighting the need for improved classification methods through broad data analysis and multidisciplinary approaches.
Purpose: To describe long-term failure pattern after early-stage breast cancer in relation to local treatment (breast-conserving therapy (BCT) or mastectomy) and age.
Materials And Methods: Cohort study with balanced 5-year age groups and prospectively collected data; 813 Danish lymph-node-negative breast cancer patients diagnosed in 1989-98 and treated with mastectomy (N=515) or BCT (N=298) and no adjuvant systemic treatment.
Results: The 20-year local recurrence (LR) risk was 20% after BCT; 8.