Publications by authors named "Christina D Papaemmanouil"

Article Synopsis
  • High-resolution NMR (nuclear magnetic resonance) spectra are essential for studying the structure and shape of organic molecules, especially those with labile protons.
  • Ma et al. (2024) showed that using 2,2,2-trifluoroacetic acid (TFA) in high concentrations improves NMR signal clarity for nitrogen-containing compounds that undergo structural changes.
  • This commentary reviews previous studies and discusses the potential of TFA to enhance NMR resolution for various organic functional groups, even at lower acid-to-solute ratios, and suggests pathways for clearer structural analysis using these labile protons.
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Natural products bear a multivariate biochemical profile with antioxidant, anti-inflammatory, antibacterial, and antitumoral properties. Along with their natural sources, they have been widely used both as anti-aging and anti-melanogenic agents due to their effective contribution in the elimination of reactive oxygen species (ROS) caused by oxidative stress. Their anti-aging activity is mainly related to their capacity of inhibiting enzymes like Human Neutrophil Elastase (HNE), Hyaluronidase (Hyal) and Tyrosinase (Tyr).

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Replacing synthetic dyes with natural pigments has gained great attention over the past years in the food industry, due to the increased alertness of consumers for nontoxic and natural additives. Betalains are water-soluble nitrogenous natural pigments that are used as natural colorants in food industries, due to their applicability and their rich pharmacological profile including antioxidant, antimicrobial, and anticancer properties. Therefore, there is a need for a detailed exploration of betalains to fully exploit their properties.

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Repurposing existing drugs, as well as natural and artificial sweeteners for novel therapeutic indications could speed up the drug discovery process since numerous associated risks and costs for drug development can be surpassed. In this study, natural and artificial sweeteners have been evaluated by and experimental studies for their potency to inhibit lipoxygenase enzyme, an enzyme participating in the inflammation pathway. A variety of different methods pinpointed that aspartame inhibits the lipoxygenase isoform 1 (LOX-1).

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In recent years, the use of species as bioactive agents is increasing exponentially. The present study aimed to investigate the chemical constituents, as well as the anti-ageing potential of the cultivated Heldr. The chemical fingerprinting of the ethyl acetate residue of this plant was studied using 1D and 2D-NMR spectra.

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species are considered as important medicinal plants with numerous health benefit effects. In continuation of our research on the Greek species, the chemical profile of the aerial parts of cultivated Griseb. has been explored.

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