Publications by authors named "Christina C Smith"

Article Synopsis
  • Etrasimod is an oral medication targeting specific receptors to treat moderately to severely active ulcerative colitis, with safety and efficacy analyzed based on prior corticosteroid use in the ELEVATE UC clinical trials.
  • In the trials, a greater percentage of patients on etrasimod achieved clinical remission compared to those on placebo, both for those currently using corticosteroids and those not, particularly noting a significant rate of corticosteroid-free remission in the corticosteroid subgroup at Week 52.
  • Safety profiles were similar across subgroups, with no increase in infection rates observed in patients using corticosteroids, demonstrating that etrasimod is effective and safe for UC patients regardless of prior corticosteroid
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Aim: To investigate the relationship between effective fentanyl sublingual spray (FSS) doses for breakthrough cancer pain (BTCP) and around-the-clock (ATC) transdermal fentanyl patch (TFP).

Methods: Adults tolerating ATC opioids received open-label FSS for 26 days, followed by a 26-day double-blind phase for patients achieving an effective dose (100-1600 µg).

Results: Out of 50 patients on ATC TFP at baseline, 32 (64%) achieved an effective dose.

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Obesity rates are high in the rural United States. Because small communities often have few health care practitioners, nutrition news in community newspapers may be a useful source of information. This content analysis of a random sample of 164 nutrition stories from 10 community newspapers in the rural West North Central Midwest was guided by concepts from goal-framing theory.

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Introduction: The management of EEG patterns in comatose intensive care unit patients remains poorly studied regarding whether aggressive management improves outcomes. We hypothesized that stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) could be classified as ictal and interictal using single-photon emission computerized tomographic (SPECT) imaging to help guide aggressive or deescalate anticonvulsant management.

Methods: We performed a retrospective review of all cases of ICU patients at a single center, tertiary care academic center for evidence of SIRPIDs with concomitant SPECT imaging over a one year period.

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Background: Imiquimod 3.75% and 2.5% creams were studied for the treatment of actinic keratosis (AK) of the full face or balding scalp, to determine comparable efficacy and tolerability to imiquimod 5% cream.

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Background: Imiquimod 3.75% and 2.5% creams were studied for the treatment of actinic keratosis (AK) of the full face or balding scalp, to determine comparable efficacy and tolerability to imiquimod 5% cream.

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Unlabelled: A 61-year-old male presented to the emergency department (ED) with painless diplopia, left-ptosis, and left downward gaze, 3 days after sustaining a fall from standing height with subsequent lumbar and head trauma. Prior to the ED consult, his only symptom was persistent generalized high intensity headache. On physical examination, no other neurological deficit was found.

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