Publications by authors named "Christina Breder"
Article Synopsis
- Therapy resistance is a key factor in cancer mortality, necessitating personalized medicine approaches, including the use of nanoparticles (NPs) designed to target specific resistance mechanisms.
- Researchers identified the ion channel LRRC8A as a critical player in cisplatin resistance in cancer cells, confirmed through advanced technologies such as next-generation sequencing and CRISPR/Cas9.
- They developed biocompatible polysarcosine-based nanoparticles loaded with cisplatin that effectively bypassed the LRRC8A transport pathway, significantly improving efficacy against cisplatin-resistant cancer cells compared to standard treatments.
